Laboratory of Molecular Biophysics
Institute of Moleclar Physiology and Genetics, Slovak Academy of Sciences, Bratislava - Sasha Zahradnikova's group
Head: Ing. Alexandra Zahradníková, PhD
alexandra.zahradnikova@savba.sk
Address:
Institute of Molecular Physiology and Genetics
Slovak Academy of Sciences
Vlárska 5, 833 34 Bratislava, Slovak Republic
Research topics:
Calcium signaling during excitation - contraction coupling in cardiac myocytes. Understanding of calcium signaling mechanisms is important for understanding how cardiac contraction is regulated in health and how it is impaired in disease, e.g., cardiac ischaemia, hypertrophy, and heart failure. We focus on the molecular mechanisms of calcium release activation, i.e., mechanisms of ryanodine receptor activation and modulation.
Techniques: whole-cell patch clamp, planar lipid bilayers, confocal microscopy, flash photolysis, advanced data analysis, mathematical modeling and simulation.
